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Roasted Butternut Squash Lasagne

Last Updated on October 6, 2023

This is a delicious alternative to the classic meat-and-tomato-sauce lasagne. The squash comes on surprisingly big; roasting it caramelizes it and concentrates its flavor. I made a relatively light “cream sauce”—half milk/half chicken broth—because the two cheeses contribute a ton of richness.

The big news here is that you don’t need to precook the lasagne noodles. Cooking lasagne on the show one night, I was demonstrating a relatively new product called “no-boil” noodles, which are somehow processed so that you don’t need to precook them. A viewer called in and volunteered that she never needed to cook the noodles for her lasagne so long as she used enough sauce. I was skeptical, but she was right. We tried it for this dish, and it works just fine.

Serves 6

1 large butternut squash, about 3 pounds, peeled, quartered, seeded, and thinly sliced
3 tablespoons vegetable oil
Kosher salt and freshly ground black pepper
2 1/2 cups whole milk
2 1/2 cups chicken stock, preferably homemade, or vegetable stock
2 tablespoons dried rosemary
2 teaspoons dried sage
5 tablespoons unsalted butter
2 garlic cloves, minced
1/4 cup plus 2 tablespoons all-purpose flour
Nine 7 x 3 1/2-inch regular or no-boil lasagne noodles
1 cup coarsely grated whole-milk mozzarella

1 1/4 cups freshly grated Parmigiano-Reggiano

Preheat the oven to 450ºF. Toss the squash with the oil in a large bowl. Season with salt and pepper and spread out in one flat layer over the bottom of a large shallow roasting pan. Roast, stirring gently or turning once or twice, until almost tender, 15 to 20 minutes.

Meanwhile, combine the milk, stock, rosemary, and sage in a large saucepan. Bring to a boil over high heat. Remove from the heat, cover, and let steep for 10 minutes. Strain, discarding the herbs. Melt the butter in a separate saucepan over medium-high heat. Add the garlic and reduce the heat to medium-low. Cook, stirring often, until the garlic is tender and fragrant, 2 to 3 minutes. Add the flour and cook, stirring, for 6 minutes. Increase the heat to high, whisk in the strained milk, and bring to a boil. Reduce the heat to medium and simmer for 5 minutes. Season with salt and pepper. Cool slightly.

Reduce the oven temperature to 375ºF and butter a 13 x 9 x 2-inch baking dish. Spread a quarter of the sauce over the bottom of the dish. Cover with 3 lasagne sheets, arranging them so that they do not touch. Arrange half the squash slices on top. Spread a third of the remaining sauce over the pasta and sprinkle on half the mozzarella and 1/2 cup of the Parmigiano-Reggiano. Make one more layer in the same manner. Top with the remaining sauce and sprinkle on the remaining 1/4 cup Parmigiano-Reggiano. Cover the dish tightly with foil, and bake in the middle of the oven for 30 minutes. Remove the foil and bake for 15 minutes longer or until bubbling. Preheat the broiler to high and set the oven rack about 6 inches from the source of heat. Broil, watching carefully, and turning to distribute the heat evenly, until golden, 2 to 3 minutes. Let stand for 5 minutes before serving.

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10 Responses to Roasted Butternut Squash Lasagne


  1. Christine Vancisin says:

    Love Sara’s TV show!

  2. Heidi says:

    I loved this recipe for the alternative to tomato sauce in the lasagna, I’m allergic to tomato’s and have been looking for other alternatives replacing tomatoes or acidic foods “for years” Thanks!

  3. ShariB says:

    Woo, hoo I am so excited to have a lasagna everyone in the family can eat. My kids are allergic to tomatoes but have a hubby who LOVES lasagna. Now everyone is happy. Especially me, because it involves butternut squash.

  4. Karen K says:

    This is absolutely delicious. First time I made it…I made a roux with the milk/broth, and cheeses. Don’t do that. I am planning to buy some frozen butternut squash to cut down on the cutting and peeling which can be a chore. Hope it works. Should make putting this wonderful lasagna… a breeze.

  5. Paula Donn says:

    Can you suggest a substitution for the flour? I cannot eat gluten. Maybe another flour type or cornstarch? Thanks for your help.

    • moulton says:

      Paula,
      I imagine one of the gluten free flours would work. King Arthur and Bob’s Red Mill both make a good one.

      • Becky says:

        For gluten free items permaflo is a good thickening alternative. It can be found in a lot of the Amish food stores.

      • Sara Moulton says:

        Thank you, that is good to know! There is also potato and cornstarch.

  6. mary clancey says:

    I have made this twice before. Can I make it in advance, how do I reheat?
    Thank you,
    Mary Clancey

    • Sara Moulton says:

      Mary,
      Alas I would not recommend making it in advance because the pasta will keep absorbing the liquid and become mushy and the dish will be dry.
      Sorry!

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